Immunogenicity Testing in Human Papillomavirus Virus‐Like‐Particle Vaccine Trials
نویسندگان
چکیده
منابع مشابه
Immunogenicity of Human Papillomavirus Recombinant Vaccine in Children with CKD.
BACKGROUND AND OBJECTIVES There is a disproportionate burden of human papillomavirus (HPV) -related genital tract disease in patients with CKD and kidney transplantation; therefore, the potential effect of the quadrivalent HPV vaccine (Gardasil; Merck GmbH, Darmstadt, Germany) is profound. Immune abnormalities associated with CKD and immunosuppression may prevent optimal vaccine response. Our o...
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Objective: Infection with various types of HPV has a causal relationship with thedevelopment of cervical cancer and other anogenital diseases. A prophylactic quadrivalent HPVvaccination has been produced. Here the pathophysiology of HPV infection and results ofmultiple HPV vaccine studies are discussed to determine efficacy and immunogenicity.Methods: The review includes art...
متن کاملQuadrivalent human papillomavirus vaccine.
The lifetime risk of human papillomavirus (HPV) infection exceeds 50%. HPV infection causes >550,000 cases of cervical and anogenital cancer worldwide annually. Infection also causes precancerous lesions and genital warts. HPV types 16 and 18 cause approximately 70% of HPV-related cancers, and HPV types 6 and 11 cause approximately 90% of cases of genital warts. A quadrivalent vaccine for HPV t...
متن کاملSafety and immunogenicity of the quadrivalent human papillomavirus vaccine in HIV-1-infected men.
BACKGROUND Human immunodeficiency virus type 1 (HIV-1)-infected men are at increased risk for anal cancer. Human papillomavirus (HPV) vaccination may prevent anal cancer caused by vaccine types. METHODS AIDS Malignancy Consortium Protocol 052 is a single-arm, open-label, multicenter clinical trial to assess the safety and immunogenicity of the quadrivalent HPV (types 6, 11, 16, and 18) vaccin...
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Background: Epidemiological studies are shown robust association between human papillomavirus (HPV) and cervical cancer. From 1990 HPV was known as a necessary but insufficient cause of cervical invasive cancer. The purpose of this study was to evaluate the cost effectiveness of HPV test in cervical cancer screening. Materials and Methods: This is a systematic review article; the newest scienti...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2009
ISSN: 0022-1899,1537-6613
DOI: 10.1086/599988